Discovery of novel Hsp90 C-terminal domain inhibitors that disrupt co-chaperone binding.

Mak, Oi Wei; Sharma, Nabangshu; Reynisson, Jóhannes; Leung, Ivanhoe K H

Mak, Oi Wei; Sharma, Nabangshu; Reynisson, Jóhannes; Leung, Ivanhoe K H.

Afiliação

Mak OW; School of Chemical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland 1142, New Zealand.
Sharma N; School of Chemical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland 1142, New Zealand.
Reynisson J; School of Chemical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland 1142, New Zealand; School of Pharmacy and Bioengineering, Hornbeam Building, Keele University, Keele, Staffordshire ST5 5BG, United Kingdom. Electronic address: j.reynisson@keele.ac.uk.
Leung IKH; School of Chemical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland 1142, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland 1142, New Zealand. Electronic address: ivanho

Bioorg Med Chem Lett ; 38: 127857, 2021 04 15.

Article em En | MEDLINE | ID: mdl-33609661

Assuntos

Descoberta de Drogas; Proteínas de Choque Térmico HSP90/antagonistas & inibidores; Chaperonas Moleculares/farmacologia; Sítios de Ligação/efeitos dos fármacos; Relação Dose-Resposta a Droga; Proteínas de Choque Térmico HSP90/metabolismo; Humanos; Modelos Moleculares; Chaperonas Moleculares/química; Estrutura Molecular; Relação Estrutura-Atividade

Palavras-chave

Cancer; Hsp90; Inhibitor; Molecular chaperone; Virtual screening

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Chaperonas Moleculares / Proteínas de Choque Térmico HSP90 / Descoberta de Drogas Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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