Clinical course of central nervous system demyelinating neurological adverse events associated with anti-TNF therapy.
J Neurol
; 268(8): 2895-2899, 2021 Aug.
Article
em En
| MEDLINE
| ID: mdl-33611609
ABSTRACT
Previous studies have reported an association between anti-tumor necrosis factor alpha (anti-TNFα) treatment and central nervous system (CNS) events. We described eight patients presenting with demyelinating CNS events while on treatment with anti-TNFα for autoimmune diseases and followed up for a medium period of 4 years. Four patients presented with isolated demyelinating events, three patients fulfilled the criteria for multiple sclerosis (MS), and one patient showed worsening of pre-existing MS after anti-TNF therapy initiation. All patients except one, showed a good medium-term prognosis. Our observation supports an association between anti-TNFα treatment and demyelinating events and suggests that a prompt discontinuation of the drug may lead to a favorable demyelinating disease outcome.
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Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
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Sistema Nervoso Central
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Doenças Desmielinizantes
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Inibidores do Fator de Necrose Tumoral
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article