Crystal structure of the non-steroidal anti-inflammatory drug (NSAID) tolmetin sodium.
Acta Crystallogr E Crystallogr Commun
; 77(Pt 2): 134-137, 2021 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-33614141
ABSTRACT
The asymmetric unit of the title compound, sodium 2-[1-methyl-5-(4-methyl-benzo-yl)-1H-pyrrol-2-yl]acetate dihydrate, Na+·C15H14NO3 -·2H2O, contains two sodium cations, two organic anions (A and B) and two water mol-ecules. The coordination geometry around the sodium cations corresponds to a distorted octa-hedron. Each pair of sodium cations (A-A or B-B) is chelated by two bridging anions coordinated by the O atoms of the deprotonated carb-oxy-lic groups, and each sodium atom is coordinated by an O atom of a third anion, which connects pairs of sodium atoms, and a water mol-ecule. As a result, a two-dimensional polymer is formed in the crystal. Hirshfeld surface analysis and two-dimensional fingerprint plots were used to analyze the inter-molecular contacts present in the crystal.
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MEDLINE
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En
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2021
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Article