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Wireless Optogenetic Modulation of Cortical Neurons Enabled by Radioluminescent Nanoparticles.
Chen, Zhaowei; Tsytsarev, Vassiliy; Finfrock, Y Zou; Antipova, Olga A; Cai, Zhonghou; Arakawa, Hiroyuki; Lischka, Fritz W; Hooks, Bryan M; Wilton, Rosemarie; Wang, Dongyi; Liu, Yi; Gaitan, Brandon; Tao, Yang; Chen, Yu; Erzurumlu, Reha S; Yang, Huanghao; Rozhkova, Elena A.
Afiliação
  • Chen Z; Center for Nanoscale Materials, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, Illinois 60439, United States.
  • Tsytsarev V; Institute of Food Safety and Environment Monitoring, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou 350108, People's Republic of China.
  • Finfrock YZ; Fischell Department of Bioengineering, University of Maryland, 8228 Paint Branch Drive, College Park, Maryland 20742, United States.
  • Antipova OA; Advanced Photon Source, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, Illinois 60439, United States.
  • Cai Z; Science Division, Canadian Light Source Inc., 44 Innovation Boulevard, Saskatoon, Saskatchewan S7N 2 V3, Canada.
  • Arakawa H; Advanced Photon Source, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, Illinois 60439, United States.
  • Lischka FW; Advanced Photon Source, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, Illinois 60439, United States.
  • Hooks BM; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, Baltimore, Maryland 21201, United States.
  • Wilton R; Biomedical Instrumentation Center, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814-4799, United States.
  • Wang D; Department of Neurobiology, University of Pittsburgh, 3500 Terrace Street, Suite W1458, Pittsburgh, Pennsylvania 15213-2500, United States.
  • Liu Y; Biosciences, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, Illinois 60439, United States.
  • Gaitan B; Fischell Department of Bioengineering, University of Maryland, 8228 Paint Branch Drive, College Park, Maryland 20742, United States.
  • Tao Y; Fischell Department of Bioengineering, University of Maryland, 8228 Paint Branch Drive, College Park, Maryland 20742, United States.
  • Chen Y; Fischell Department of Bioengineering, University of Maryland, 8228 Paint Branch Drive, College Park, Maryland 20742, United States.
  • Erzurumlu RS; Fischell Department of Bioengineering, University of Maryland, 8228 Paint Branch Drive, College Park, Maryland 20742, United States.
  • Yang H; Fischell Department of Bioengineering, University of Maryland, 8228 Paint Branch Drive, College Park, Maryland 20742, United States.
  • Rozhkova EA; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, Baltimore, Maryland 21201, United States.
ACS Nano ; 15(3): 5201-5208, 2021 03 23.
Article em En | MEDLINE | ID: mdl-33625219
ABSTRACT
While offering high-precision control of neural circuits, optogenetics is hampered by the necessity to implant fiber-optic waveguides in order to deliver photons to genetically engineered light-gated neurons in the brain. Unlike laser light, X-rays freely pass biological barriers. Here we show that radioluminescent Gd2(WO4)3Eu nanoparticles, which absorb external X-rays energy and then downconvert it into optical photons with wavelengths of ∼610 nm, can be used for the transcranial stimulation of cortical neurons expressing red-shifted, ∼590-630 nm, channelrhodopsin ReaChR, thereby promoting optogenetic neural control to the practical implementation of minimally invasive wireless deep brain stimulation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nanopartículas / Optogenética Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nanopartículas / Optogenética Idioma: En Ano de publicação: 2021 Tipo de documento: Article