INSM1 Expression in Chordomas.
Am J Clin Pathol
; 156(3): 334-339, 2021 08 04.
Article
em En
| MEDLINE
| ID: mdl-33629710
ABSTRACT
OBJECTIVES:
Chordomas are rare malignant tumors with a broad differential diagnosis, including chondrosarcomas and metastatic carcinomas. Recently, insulinoma-associated protein 1 (INSM1) has gained great interest regarding the diagnosis of neuroendocrine tumors but also extraskeletal myxoid chondrosarcomas. However, its expression in chordomas remains largely unknown.METHODS:
We retrospectively examined 57 chordomas for INSM1 expression.RESULTS:
INSM1 expression was found in only 5% of tumors.CONCLUSIONS:
This marker is rarely expressed in this type of tumor, raising questions about neuroendocrine differentiation.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
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Cordoma
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Carcinoma
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Condrossarcoma
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Tumores Neuroendócrinos
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Neoplasias de Tecido Conjuntivo e de Tecidos Moles
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article