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Bromelain inhibits SARS-CoV-2 infection via targeting ACE-2, TMPRSS2, and spike protein.
Sagar, Satish; Rathinavel, Ashok Kumar; Lutz, William E; Struble, Lucas R; Khurana, Surender; Schnaubelt, Andy T; Mishra, Nitish Kumar; Guda, Chittibabu; Palermo, Nicholas Y; Broadhurst, Mara J; Hoffmann, Tobias; Bayles, Kenneth W; Reid, St Patrick M; Borgstahl, Gloria E O; Radhakrishnan, Prakash.
Afiliação
  • Sagar S; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Rathinavel AK; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Lutz WE; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Struble LR; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Khurana S; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, Maryland, USA.
  • Schnaubelt AT; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Mishra NK; Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Guda C; Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Palermo NY; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Broadhurst MJ; Computational Chemistry Core, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Hoffmann T; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Bayles KW; Advanced Light and Electron Microscopy, Centre for Biological Threats and Special Pathogens 4 (ZBS 4), Robert Koch Institute, Berlin, Germany.
  • Reid SPM; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Borgstahl GEO; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Radhakrishnan P; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Clin Transl Med ; 11(2): e281, 2021 02.
Article em En | MEDLINE | ID: mdl-33635001
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Serina Endopeptidases / Bromelaínas / Glicoproteína da Espícula de Coronavírus / Enzima de Conversão de Angiotensina 2 / SARS-CoV-2 / COVID-19 / Tratamento Farmacológico da COVID-19 Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Serina Endopeptidases / Bromelaínas / Glicoproteína da Espícula de Coronavírus / Enzima de Conversão de Angiotensina 2 / SARS-CoV-2 / COVID-19 / Tratamento Farmacológico da COVID-19 Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article