Liver Metastasis Irradiation Can Restore Immunotherapeutic Responsiveness.

Demaria, Sandra; Formenti, Silvia C

Demaria, Sandra; Formenti, Silvia C.

Afiliação

Demaria S; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA. Electronic address: szd3005@med.cornell.edu.
Formenti SC; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.

Trends Immunol ; 42(4): 275-277, 2021 04.

Article em En | MEDLINE | ID: mdl-33637449

ABSTRACT

ABSTRACT

Allogeneic liver transplants tolerize the immune system, preventing organ rejection from the same donor. A recent article by Yu et al. shows that liver metastases can likewise prevent tumor rejection in immunotherapy-treated murine and human hosts. Furthermore, radiation can reprogram the liver microenvironment to restore systemic tumor rejection.

Assuntos

Neoplasias Hepáticas; Linfócitos T; Animais; Humanos; Imunoterapia; Neoplasias Hepáticas/terapia; Macrófagos; Camundongos; Microambiente Tumoral

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T / Neoplasias Hepáticas Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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