Determinants of prolonged viral RNA shedding in hospitalized patients with SARS-CoV-2 infection.
Diagn Microbiol Infect Dis
; 100(2): 115347, 2021 Jun.
Article
em En
| MEDLINE
| ID: mdl-33639375
ABSTRACT
OBJECTIVE:
To evaluate determinants of prolonged viral RNA shedding in hospitalized patients with SARS-CoV-2 infection. MATERIALS ANDMETHODS:
Hospitalized patients with SARS-CoV-2 positive nasopharyngeal RT-PCR were included in a single-center, retrospective study. Patients were divided in 2 groups according to the timing of viral clearance [≤14 days, "early clearance (EC)" and >14 days, "late clearance (LC)"].RESULTS:
179 patients were included in the study (101 EC, 78 LC), with median age 62 years. Median time of viral shedding was 14 days (EC/LC 10 and 19 days, respectively, P < 0.0001). Univariate analyses showed that age, male gender, receiving corticosteroids, receiving tocilizumab, ICU admission, low albumin and NLR ratio were associated with late viral clearance. In the multivariable analysis, older age (P = 0.016), albumin level (P = 0.048), corticosteroids (P = 0.021), and tocilizumab (P = 0.015) were significantly associated with late viral clearance.CONCLUSIONS:
Age, albumin, tocilizumab and corticosteroid treatment were independently associated with a prolonged SARS-CoV-2 RNA shedding.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA Viral
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Eliminação de Partículas Virais
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SARS-CoV-2
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COVID-19
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article