Amphiol, an Antifungal Fungal Pigment from Pseudogymnoascus sp. PF1464.
J Nat Prod
; 84(4): 986-992, 2021 04 23.
Article
em En
| MEDLINE
| ID: mdl-33646775
ABSTRACT
An antifungal metabolite, designated amphiol (1), was isolated from the culture broth of the fungus Pseudogymnoascus sp. PF1464. It exists as a mixture of inseparable tautomers, an acetal form and a keto form. The chemical structure was determined by spectroscopic analyses and chemical derivatization. Amphiol (1) showed antifungal but not antibacterial activities, while yeast mutant cells lacking ergosterol biosynthetic genes were less sensitive, implying a fungal specific, membrane-related mechanism of action.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pigmentos Biológicos
/
Ascomicetos
/
Antifúngicos
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article