Nanog is a promising chemoresistant stemness marker and therapeutic target by iron chelators for esophageal cancer.

Narusaka, Toru; Ohara, Toshiaki; Noma, Kazuhiro; Nishiwaki, Noriyuki; Katsura, Yuki; Kato, Takuya; Sato, Hiroaki; Tomono, Yasuko; Kikuchi, Satoru; Tazawa, Hiroshi; Shirakawa, Yasuhiro; Matsukawa, Akihiro; Fujiwara, Toshiyoshi

Narusaka, Toru; Ohara, Toshiaki; Noma, Kazuhiro; Nishiwaki, Noriyuki; Katsura, Yuki; Kato, Takuya; Sato, Hiroaki; Tomono, Yasuko; Kikuchi, Satoru; Tazawa, Hiroshi; Shirakawa, Yasuhiro; Matsukawa, Akihiro; Fujiwara, Toshiyoshi.

Afiliação

Narusaka T; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Ohara T; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Noma K; Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Nishiwaki N; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Katsura Y; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Kato T; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Sato H; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Tomono Y; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Kikuchi S; Division of Molecular Cell biology, Shigei Medical Research Institute, Okayama, Japan.
Tazawa H; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Shirakawa Y; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Matsukawa A; Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan.
Fujiwara T; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Int J Cancer ; 149(2): 347-357, 2021 07 15.

Article em En | MEDLINE | ID: mdl-33662150

Assuntos

Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; Neoplasias Esofágicas/tratamento farmacológico; Perfilação da Expressão Gênica/métodos; Quelantes de Ferro/administração & dosagem; Proteína Homeobox Nanog/genética; Proteína Homeobox Nanog/metabolismo; Animais; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Cisplatino/farmacologia; Neoplasias Esofágicas/genética; Neoplasias Esofágicas/metabolismo; Feminino; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Quelantes de Ferro/farmacologia; Masculino; Camundongos; Proteína Homeobox Nanog/efeitos dos fármacos; Células-Tronco Neoplásicas/efeitos dos fármacos; Células-Tronco Neoplásicas/metabolismo; Prognóstico; Análise de Sequência de RNA; Regulação para Cima/efeitos dos fármacos; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

cancer stem cells; chelator; esophageal cancer; iron; stemness

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / Quelantes de Ferro / Resistencia a Medicamentos Antineoplásicos / Perfilação da Expressão Gênica / Proteína Homeobox Nanog Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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