No pains, no gains: how chromosome fragmentation promotes gene amplification.
Mol Cell
; 81(5): 901-904, 2021 03 04.
Article
em En
| MEDLINE
| ID: mdl-33667381
ABSTRACT
Combining live-cell imaging, cytogenetics, genome sequencing, and in vitro evolution, Shoshani et al. (2020) revealed deep connections between chromothripsis, the catastrophic shattering of a chromosome in abnormal nuclear structures, and gene amplification, a frequent culprit of oncogenic activation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cromotripsia
/
Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article