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Phosphoinositide 3-Kinase (PI3K) Reactive Oxygen Species (ROS)-Activated Prodrug in Combination with Anthracycline Impairs PI3K Signaling, Increases DNA Damage Response and Reduces Breast Cancer Cell Growth.
Mishra, Rosalin; Yuan, Long; Patel, Hima; Karve, Aniruddha S; Zhu, Haizhou; White, Aaron; Alanazi, Samar; Desai, Pankaj; Merino, Edward J; Garrett, Joan T.
Afiliação
  • Mishra R; Department of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
  • Yuan L; Department of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
  • Patel H; Department of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
  • Karve AS; Department of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
  • Zhu H; Department of Chemistry, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
  • White A; Department of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
  • Alanazi S; Department of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
  • Desai P; Department of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
  • Merino EJ; Department of Chemistry, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
  • Garrett JT; Department of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
Int J Mol Sci ; 22(4)2021 Feb 19.
Article em En | MEDLINE | ID: mdl-33669867
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Neoplasias da Mama / Pró-Fármacos / Transdução de Sinais / Espécies Reativas de Oxigênio / Antraciclinas / Fosfatidilinositol 3-Quinases Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Neoplasias da Mama / Pró-Fármacos / Transdução de Sinais / Espécies Reativas de Oxigênio / Antraciclinas / Fosfatidilinositol 3-Quinases Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article