Interorganelle communication and membrane shaping in the early secretory pathway.
Curr Opin Cell Biol
; 71: 95-102, 2021 08.
Article
em En
| MEDLINE
| ID: mdl-33711785
ABSTRACT
Biomolecules in the secretory pathway use membrane trafficking for reaching their final intracellular destination or for secretion outside the cell. This highly dynamic and multipartite process involves different organelles that communicate to one another while maintaining their identity, shape, and function. Recent studies unraveled new mechanisms of interorganelle communication that help organize the early secretory pathway. We highlight how the spatial proximity between endoplasmic reticulum (ER) exit sites and early Golgi elements provides novel means of ER-Golgi communication for ER export. We also review recent findings on how membrane contact sites between the ER and the trans-Golgi membranes can sustain anterograde traffic out of the Golgi complex.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Via Secretória
/
Complexo de Golgi
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article