Secondary substitutions in the hemagglutinin and neuraminidase genes associated with neuraminidase inhibitor resistance are rare in the Influenza Resistance Information Study (IRIS).

Roosenhoff, Rueshandra; Schutten, Martin; Reed, Vaughan; Clinch, Barry; van der Linden, Anne; Fouchier, Ron A M; Fraaij, Pieter L A

Roosenhoff, Rueshandra; Schutten, Martin; Reed, Vaughan; Clinch, Barry; van der Linden, Anne; Fouchier, Ron A M; Fraaij, Pieter L A.

Afiliação

Roosenhoff R; Department of Viroscience, Erasmus Medical Center, Rotterdam, 3015GE, the Netherlands.
Schutten M; Clinical Virology and Diagnostics, 1817HL, Alkmaar, the Netherlands.
Reed V; Micron, Ely, CB7 4AF, United Kingdom.
Clinch B; Roche Products Ltd, Welwyn Garden City, AL7 1TW, United Kingdom.
van der Linden A; Department of Viroscience, Erasmus Medical Center, Rotterdam, 3015GE, the Netherlands.
Fouchier RAM; Department of Viroscience, Erasmus Medical Center, Rotterdam, 3015GE, the Netherlands.
Fraaij PLA; Department of Viroscience, Erasmus Medical Center, Rotterdam, 3015GE, the Netherlands; Department of Pediatrics, Subdivision Infectious Diseases and Immunology, Erasmus Medical Center - Sophia, Rotterdam, the Netherlands. Electronic address: p.fraaij@erasmusmc.nl.

Antiviral Res ; 189: 105060, 2021 05.

Article em En | MEDLINE | ID: mdl-33713731

Assuntos

Antivirais/farmacologia; Farmacorresistência Viral; Hemaglutininas/genética; Influenza Humana/virologia; Neuraminidase/genética; Orthomyxoviridae/efeitos dos fármacos; Orthomyxoviridae/genética; Substituição de Aminoácidos; Inibidores Enzimáticos/farmacologia; Aptidão Genética; Humanos; Vírus da Influenza A Subtipo H3N2/efeitos dos fármacos; Vírus da Influenza A Subtipo H3N2/genética; Influenza Humana/tratamento farmacológico; Mutação de Sentido Incorreto; Oseltamivir/farmacologia; Estudos Prospectivos; RNA Viral; Proteínas Virais

Palavras-chave

IRIS study; Influenza; Next-generation sequencing; Oseltamivir; Resistance

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Orthomyxoviridae / Farmacorresistência Viral / Influenza Humana / Hemaglutininas / Neuraminidase Tipo de estudo: Clinical_trials / Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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