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Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia.
Mackinnon, Sabrina R; Krojer, Tobias; Foster, William R; Diaz-Saez, Laura; Tang, Manshu; Huber, Kilian V M; von Delft, Frank; Lai, Kent; Brennan, Paul E; Arruda Bezerra, Gustavo; Yue, Wyatt W.
Afiliação
  • Mackinnon SR; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, OX3 7DQ.
  • Krojer T; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, OX3 7DQ.
  • Foster WR; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, OX3 7DQ.
  • Diaz-Saez L; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, OX3 7DQ.
  • Tang M; Target Discovery Institute, University of Oxford, Oxford, United Kingdom, OX3 7FZ.
  • Huber KVM; Department of Pediatrics, University of Utah, Salt Lake City, Utah 84108-6500, United States.
  • von Delft F; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, OX3 7DQ.
  • Lai K; Target Discovery Institute, University of Oxford, Oxford, United Kingdom, OX3 7FZ.
  • Brennan PE; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, OX3 7DQ.
  • Arruda Bezerra G; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, United Kingdom, OX11 0DE.
  • Yue WW; Department of Pediatrics, University of Utah, Salt Lake City, Utah 84108-6500, United States.
ACS Chem Biol ; 16(4): 586-595, 2021 04 16.
Article em En | MEDLINE | ID: mdl-33724769
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Galactoquinase / Galactosemias Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Galactoquinase / Galactosemias Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article