Microcephaly Outcomes among Zika Virus-Infected Pregnant Women in Honduras.
Am J Trop Med Hyg
; 104(5): 1737-1740, 2021 03 15.
Article
em En
| MEDLINE
| ID: mdl-33724927
ABSTRACT
The impact of Zika virus (ZIKV) infection on pregnancies shows regional variation emphasizing the importance of studies in different geographical areas. We conducted a prospective study in Tegucigalpa, Honduras, recruiting 668 pregnant women between July 20, 2016, and December 31, 2016. We performed Trioplex real-time reverse transcriptase-PCR (rRT-PCR) in 357 serum samples taken at the first prenatal visit. The presence of ZIKV was confirmed in seven pregnancies (7/357, 2.0%). Nine babies (1.6%) had microcephaly (head circumference more than two SDs below the mean), including two (0.3%) with severe microcephaly (head circumference [HC] more than three SDs below the mean). The mothers of both babies with severe microcephaly had evidence of ZIKV infection. A positive ZIKV Trioplex rRT-PCR was associated with a 33.3% (95% CI 4.3-77.7%) risk of HC more than three SDs below the mean.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complicações Infecciosas na Gravidez
/
Zika virus
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Infecção por Zika virus
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Microcefalia
Tipo de estudo:
Diagnostic_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Pregnancy
País como assunto:
America central
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Honduras
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article