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Myoepithelial Carcinoma of Soft Tissue With an EWSR1-KLF15 Gene Fusion in an Infant.
Bodis, Sandor; Kroiss, Sabine; Tchinda, Joëlle; Fritz, Christine; Wagner, Ulrich; Bode, Peter Karl.
Afiliação
  • Bodis S; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zürich, Switzerland.
  • Kroiss S; Department of Oncology, University Children's Hospital Zürich, Zürich, Switzerland.
  • Tchinda J; Department of Oncology, University Children's Hospital Zürich, Zürich, Switzerland.
  • Fritz C; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zürich, Switzerland.
  • Wagner U; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zürich, Switzerland.
  • Bode PK; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zürich, Switzerland.
Pediatr Dev Pathol ; 24(4): 371-377, 2021.
Article em En | MEDLINE | ID: mdl-33734915
ABSTRACT
Overall, neonatal cancer is uncommon. Because of its rarity and heterogeneity, diagnosis can be challenging. We report a unique case of a myoepithelial carcinoma in a 7 week old girl. Molecular diagnostic workup revealed a EWSR1-KLF15 gene fusion which was previously described in only six cases of myoepithelial tumors so far. All cases occurred in children and adolescents. To our knowledge, this is the first report of a congenital EWSR1-KLF15 fusion positive myoepithelial tumor in an infant.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias de Tecidos Moles / Biomarcadores Tumorais / Mioepitelioma / Proteína EWS de Ligação a RNA / Fatores de Transcrição Kruppel-Like / Fusão Gênica Tipo de estudo: Diagnostic_studies Limite: Female / Humans / Infant Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias de Tecidos Moles / Biomarcadores Tumorais / Mioepitelioma / Proteína EWS de Ligação a RNA / Fatores de Transcrição Kruppel-Like / Fusão Gênica Tipo de estudo: Diagnostic_studies Limite: Female / Humans / Infant Idioma: En Ano de publicação: 2021 Tipo de documento: Article