Complement cascade in severe forms of COVID-19: Recent advances in therapy.
Eur J Immunol
; 51(7): 1652-1659, 2021 07.
Article
em En
| MEDLINE
| ID: mdl-33738806
ABSTRACT
The complement system is an essential component of the innate immune system. The three complement pathways (classical, lectin, alternative) are directly or indirectly activated by the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). In the most severe forms of COVID-19, overactivation of the complement system may contribute to the cytokine storm, endothelial inflammation (endotheliitis) and thrombosis. No antiviral drug has yet been shown to be effective in COVID-19. Therefore, immunotherapies represent a promising therapeutic in the immunopathological phase (following the viral phase) of the disease. Complement blockade, mostly C5a-C5aR axis blockade, may prevent acute respiratory distress syndrome (ARDS) from worsening or progression to death. Clinical trials are underway.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complemento C5a
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Citocinas
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Receptor da Anafilatoxina C5a
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Síndrome da Liberação de Citocina
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COVID-19
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Imunoterapia
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article