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Novel approaches for vaccine development.
Gebre, Makda S; Brito, Luis A; Tostanoski, Lisa H; Edwards, Darin K; Carfi, Andrea; Barouch, Dan H.
Afiliação
  • Gebre MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
  • Brito LA; Moderna, Inc., Cambridge, MA, USA.
  • Tostanoski LH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Edwards DK; Moderna, Inc., Cambridge, MA, USA.
  • Carfi A; Moderna, Inc., Cambridge, MA, USA; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA. Electronic address: andrea.carfi@modernatx.com.
  • Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA. Electronic address: dbarouch@bidmc.
Cell ; 184(6): 1589-1603, 2021 03 18.
Article em En | MEDLINE | ID: mdl-33740454
ABSTRACT
Vaccines are critical tools for maintaining global health. Traditional vaccine technologies have been used across a wide range of bacterial and viral pathogens, yet there are a number of examples where they have not been successful, such as for persistent infections, rapidly evolving pathogens with high sequence variability, complex viral antigens, and emerging pathogens. Novel technologies such as nucleic acid and viral vector vaccines offer the potential to revolutionize vaccine development as they are well-suited to address existing technology limitations. In this review, we discuss the current state of RNA vaccines, recombinant adenovirus vector-based vaccines, and advances from biomaterials and engineering that address these important public health challenges.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas Sintéticas / Vacinas contra COVID-19 / SARS-CoV-2 / COVID-19 Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas Sintéticas / Vacinas contra COVID-19 / SARS-CoV-2 / COVID-19 Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article