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Complexity index in sarcoma and genomic grade index gene signatures in rhabdomyosarcoma of pediatric and adult ages.
Ferrari, Andrea; Iannó, Maria Federica; Carenzo, Andrea; Fortunato, Orazio; Casanova, Michela; Chiaravalli, Stefano; Bergamaschi, Luca; Bertulli, Rossella; Cattaneo, Francesca; Collini, Paola; Trama, Annalisa; Sozzi, Gabriella; Massimino, Maura; De Cecco, Loris; Gasparini, Patrizia.
Afiliação
  • Ferrari A; Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, 20133, Italy.
  • Iannó MF; Integrated Biology Platform, Department of Applied Research and Technology Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, 20133, Italy.
  • Carenzo A; Integrated Biology Platform, Department of Applied Research and Technology Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, 20133, Italy.
  • Fortunato O; Tumor Genomics Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy.
  • Casanova M; Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, 20133, Italy.
  • Chiaravalli S; Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, 20133, Italy.
  • Bergamaschi L; Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, 20133, Italy.
  • Bertulli R; Adult Mesenchymal Tumor and Rare Cancer Medical Oncology Unit, Medical Oncology and Hematology Department, Fondazione IRCCS Istituto Nazionale Tumori,  , Milan, 20133, Italy.
  • Cattaneo F; University of Milano School of Medicine, Milano, Italy.
  • Collini P; Soft Tissue and Bone Pathology, and Pediatric Pathology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, 20133, Italy.
  • Trama A; Evaluative Epidemiology, Fondazione IRCCS Nazionale dei Tumori, Milan, 20133, Italy.
  • Sozzi G; Tumor Genomics Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy.
  • Massimino M; Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, 20133, Italy.
  • De Cecco L; Integrated Biology Platform, Department of Applied Research and Technology Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, 20133, Italy.
  • Gasparini P; Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, 20133, Italy.
Pediatr Blood Cancer ; 68(7): e28987, 2021 07.
Article em En | MEDLINE | ID: mdl-33751795
BACKGROUND: Rhabdomyosarcoma (RMS), the most frequent soft-tissue sarcoma in childhood, shows extensive heterogeneity in histology, site and age of onset, clinical course, and prognosis. Adolescents and young adults (AYA) with RMS form a subgroup of patients whose survival lacks behind that of children while diagnosed with histologically similar tumors. PROCEDURES: A 67-gene prognostic signature related to chromosome integrity, mitotic control, and genome complexity in sarcomas (CINSARC) is considered a powerful tool for identifying tumors with a highly metastatic potential. With this study, we investigated the prognostic value of CINSARC signature on a cohort of 48 pediatric (PEDs) and AYAs-RMS. RESULTS: CINSARC resulted not significantly correlated with age, suggesting other determinants to be responsible for that difference in survival. It remained a significant prognostic variable in both the groups of PEDs and AYAs. Also, genomic grade index signature was tested on the same cohort and showed very similar results with CINSARC. CONCLUSIONS: Our study showed that CINSARC correlated with outcome in RMS patients and may be potentially considered a tool to predict outcome, and so stratify RMS patients.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rabdomiossarcoma Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Child / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rabdomiossarcoma Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Child / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article