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The COVIDome Explorer Researcher Portal.
Sullivan, Kelly D; Galbraith, Matthew D; Kinning, Kohl T; Bartsch, Kyle; Levinsky, Nik; Araya, Paula; Smith, Keith P; Granrath, Ross E; Shaw, Jessica R; Baxter, Ryan; Jordan, Kimberly R; Russell, Seth; Dzieciatkowska, Monika; Reisz, Julie A; Gamboni, Fabia; Cendali, Francesca; Ghosh, Tusharkanti; Monte, Andrew A; Bennett, Tellen D; Miller, Michael G; Hsieh, Elena W Y; D'Alessandro, Angelo; Hansen, Kirk C; Espinosa, Joaquin M.
Afiliação
  • Sullivan KD; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Galbraith MD; Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Kinning KT; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Bartsch K; Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Levinsky N; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Araya P; Information Services, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Smith KP; Information Services, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Granrath RE; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Shaw JR; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Baxter R; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Jordan KR; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Russell S; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Dzieciatkowska M; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Reisz JA; Data Science to Patient Value, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Gamboni F; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Cendali F; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Ghosh T; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Monte AA; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Bennett TD; Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO, USA.
  • Miller MG; Department of Emergency Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Hsieh EWY; Department of Pediatrics, Sections of Informatics and Data Science and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • D'Alessandro A; Information Services, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Hansen KC; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Espinosa JM; Department of Pediatrics, Division of Allergy/Immunology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
medRxiv ; 2021 Mar 08.
Article em En | MEDLINE | ID: mdl-33758879
ABSTRACT
COVID-19 pathology involves dysregulation of diverse molecular, cellular, and physiological processes. In order to expedite integrated and collaborative COVID-19 research, we completed multi-omics analysis of hospitalized COVID-19 patients including matched analysis of the whole blood transcriptome, plasma proteomics with two complementary platforms, cytokine profiling, plasma and red blood cell metabolomics, deep immune cell phenotyping by mass cytometry, and clinical data annotation. We refer to this multidimensional dataset as the COVIDome. We then created the COVIDome Explorer, an online researcher portal where the data can be analyzed and visualized in real time. We illustrate here the use of the COVIDome dataset through a multi-omics analysis of biosignatures associated with C-reactive protein (CRP), an established marker of poor prognosis in COVID-19, revealing associations between CRP levels and damage-associated molecular patterns, depletion of protective serpins, and mitochondrial metabolism dysregulation. We expect that the COVIDome Explorer will rapidly accelerate data sharing, hypothesis testing, and discoveries worldwide.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article