Advances in intranasal application of stem cells in the treatment of central nervous system diseases.
Stem Cell Res Ther
; 12(1): 210, 2021 03 24.
Article
em En
| MEDLINE
| ID: mdl-33762014
ABSTRACT
Stem cells are characterized by their self-renewal and multipotency and have great potential in the therapy of various disorders. However, the blood-brain barrier (BBB) limits the application of stem cells in the therapy of neurological disorders, especially in a noninvasive way. It has been shown that small molecular substances, macromolecular proteins, and even stem cells can bypass the BBB and reach the brain parenchyma following intranasal administration. Here, we review the possible brain-entry routes of transnasal treatment, the cell types, and diseases involved in intranasal stem cell therapy, and discuss its advantages and disadvantages in the treatment of central nervous system diseases, to provide a reference for the application of intranasal stem cell therapy.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Doenças do Sistema Nervoso Central
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article