MiR-130a Acts as a Tumor Suppressor MicroRNA in Cutaneous Squamous Cell Carcinoma and Regulates the Activity of the BMP/SMAD Pathway by Suppressing ACVR1.

Lohcharoenkal, Warangkana; Li, Chen; Das Mahapatra, Kunal; Lapins, Jan; Homey, Bernhard; Sonkoly, Eniko; Pivarcsi, Andor

Lohcharoenkal, Warangkana; Li, Chen; Das Mahapatra, Kunal; Lapins, Jan; Homey, Bernhard; Sonkoly, Eniko; Pivarcsi, Andor.

Afiliação

Lohcharoenkal W; Dermatology and Venereology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Li C; Dermatology and Venereology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Das Mahapatra K; Dermatology and Venereology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Lapins J; Unit of Dermatology and Venereology, Karolinska University Hospital, Stockholm, Sweden.
Homey B; Department of Dermatology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Sonkoly E; Dermatology and Venereology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Unit of Dermatology and Venereology, Karolinska University Hospital, Stockholm, Sweden.
Pivarcsi A; Dermatology and Venereology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden. Electronic address: Andor.P

J Invest Dermatol ; 141(8): 1922-1931, 2021 08.

Article em En | MEDLINE | ID: mdl-33766507

Assuntos

Receptores de Ativinas Tipo I/genética; Carcinoma de Células Escamosas/genética; Ceratose Actínica/genética; MicroRNAs/metabolismo; Neoplasias Cutâneas/genética; Animais; Biópsia; Carcinoma de Células Escamosas/patologia; Linhagem Celular Tumoral; Movimento Celular/genética; Proliferação de Células/genética; Transformação Celular Neoplásica/genética; Regulação para Baixo; Regulação Neoplásica da Expressão Gênica; Genes Supressores de Tumor; Humanos; Queratinócitos/patologia; Ceratose Actínica/patologia; Sistema de Sinalização das MAP Quinases/genética; Camundongos; Neoplasias Cutâneas/patologia; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Carcinoma de Células Escamosas / Receptores de Ativinas Tipo I / MicroRNAs / Ceratose Actínica Tipo de estudo: Observational_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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