Mutational spectrum in clinically aggressive low-grade serous carcinoma/serous borderline tumors of the ovary-Clinical significance of BRCA2 gene variants in genomically stable tumors.

Zhang, Xiaoming; Devins, Kyle; Ko, Emily M; Reyes, Maria Carolina; Simpkins, Fiona; Drapkin, Ronny; Schwartz, Lauren E; Yoon, Ju-Yoon

Zhang, Xiaoming; Devins, Kyle; Ko, Emily M; Reyes, Maria Carolina; Simpkins, Fiona; Drapkin, Ronny; Schwartz, Lauren E; Yoon, Ju-Yoon.

Afiliação

Zhang X; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Devins K; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Ko EM; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Reyes MC; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Simpkins F; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Drapkin R; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Schwartz LE; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Yoon JY; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA; Department of Pathology, St. Michael's Hospital, Toronto, Ontario, Canada. Electronic address: juyoon.yoon@utoronto.ca.

Gynecol Oncol ; 161(3): 762-768, 2021 06.

Article em En | MEDLINE | ID: mdl-33773808

Assuntos

Proteína BRCA2/genética; Cistadenocarcinoma Seroso/genética; Predisposição Genética para Doença; Neoplasias Ovarianas/genética; Adolescente; Adulto; Idoso; Cistadenocarcinoma Seroso/mortalidade; Cistadenocarcinoma Seroso/patologia; Feminino; Humanos; Pessoa de Meia-Idade; Gradação de Tumores; Metástase Neoplásica; Neoplasias Ovarianas/mortalidade; Neoplasias Ovarianas/patologia; Pennsylvania; Adulto Jovem

Palavras-chave

BRCA2; Homologous recombination pathway; Low-grade serous ovarian carcinoma; PARP inhibitor; Serous borderline tumor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Cistadenocarcinoma Seroso / Predisposição Genética para Doença / Proteína BRCA2 Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Aged / Female / Humans / Middle aged País como assunto: America do norte Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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