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Left Atrial Strain in the Repaired Tetralogy of Fallot Population: Comparisons to Biventricular Function, Native T1 Values, Exercise Parameters and Healthy Controls.
Ta, Hieu T; Truong, Vien T; Alsaied, Tarek; Critser, Paul J; Germann, Joshua; Ollberding, Nicholas J; Khoury, Philip R; Powell, Adam W; Lang, Sean; Mazur, Wojciech; Redington, Andrew N; Tretter, Justin T.
Afiliação
  • Ta HT; Heart Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 2003, Cincinnati, OH, 45229, USA.
  • Truong VT; Department of Cardiology, The Christ Hospital Health Network, Cincinnati, OH, USA.
  • Alsaied T; Heart Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 2003, Cincinnati, OH, 45229, USA.
  • Critser PJ; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Germann J; Heart Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 2003, Cincinnati, OH, 45229, USA.
  • Ollberding NJ; Heart Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 2003, Cincinnati, OH, 45229, USA.
  • Khoury PR; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Powell AW; Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
  • Lang S; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Mazur W; Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
  • Redington AN; Heart Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 2003, Cincinnati, OH, 45229, USA.
  • Tretter JT; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Pediatr Cardiol ; 42(5): 1102-1110, 2021 Jun.
Article em En | MEDLINE | ID: mdl-33774693
ABSTRACT

BACKGROUND:

Non-invasive imaging markers in patients with repaired tetralogy of Fallot (rTOF) are still being investigated to inform clinical decision making. Atrial function is a prognostic indicator in many acquired and congenital heart diseases. We sought to examine the relationship between cardiac MRI (CMR)-derived indices of left atrial (LA) function, native left ventricular (LV) T1 values, biventricular systolic function, and exercise capacity in rTOF.

METHODS:

Sixty-six patients with rTOF without prior pulmonary valve replacement who underwent CMR (median age 18.5 years) were identified. Twenty-one adult rTOF patients (age range 19-32 years) were compared with 20 age-matched healthy volunteers (age range 19-34 years). LA reservoir, conduit, and pump global longitudinal strain (GLS) and strain rate (SR) were determined by tissue tracking. Native LV T1 values were measured on rTOF patients. Pearson correlations were performed to determine bivariate associations.

RESULTS:

Adult rTOF patients had higher pump GLS, pumpconduit, and pumpreservoir GLS ratios, and lower conduitreservoir GLS ratio, LV ejection fraction (EF), and right ventricular EF compared to controls (p < 0.001 for each comparison). LA conduitreservoir GLS and pumpreservoir GLS had correlations to native LV T1 (ρ = 0.26, p = 0.03 and ρ = - 0.26, p = 0.03, respectively). LA reservoir SR had positive correlation to RV EF (ρ = 0.27, p = 0.03). There were no statistically significant correlations between LA function and exercise capacity.

CONCLUSIONS:

LA function is altered in adolescent and young adult patients with rTOF indicating worse diastolic function and relates to increasing native LV T1 values. Future studies are indicated to investigate the progression of adverse atrial-ventricular interactions and poor outcomes in this population.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tetralogia de Fallot / Função do Átrio Esquerdo / Procedimentos Cirúrgicos Cardíacos / Ventrículos do Coração Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tetralogia de Fallot / Função do Átrio Esquerdo / Procedimentos Cirúrgicos Cardíacos / Ventrículos do Coração Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article