Successful Pregnancies in a Patient with Childhood-onset Steroid-dependent Nephrotic Syndrome during Rituximab Maintenance Therapy.
Intern Med
; 60(18): 2985-2989, 2021 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-33776000
ABSTRACT
There are an increasing number of reports on the safe use of rituximab (RTX), a chimeric anti-CD20 monoclonal antibody, in pregnant women with hematological malignancies or refractory autoimmune diseases. In 2014, the use of RTX for patients with complicated steroid-dependent nephrotic syndrome (SDNS) was approved in Japan. We herein report a woman with childhood-onset complicated SDNS due to focal and segmental glomerulosclerosis, who had two successful pregnancies while receiving RTX maintenance therapy. No adverse complications were observed during the pregnancies, and she delivered healthy newborns. This case suggested that RTX may be used safely in pregnant women complicated with SDNS.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Glomerulosclerose Segmentar e Focal
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Síndrome Nefrótica
Limite:
Child
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Female
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Humans
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Newborn
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Pregnancy
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article