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A noncanonical FLT3 gatekeeper mutation disrupts gilteritinib binding and confers resistance.
Joshi, Sunil K; Sharzehi, Setareh; Pittsenbarger, Janét; Bottomly, Daniel; Tognon, Cristina E; McWeeney, Shannon K; Druker, Brian J; Traer, Elie.
Afiliação
  • Joshi SK; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.
  • Sharzehi S; Department of Physiology & Pharmacology, School of Medicine, Oregon Health & Science University, Portland, Oregon, USA.
  • Pittsenbarger J; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA.
  • Bottomly D; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.
  • Tognon CE; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA.
  • McWeeney SK; Department of Cell, Development, & Cancer Biology, Oregon Health & Science University, Portland, Oregon, USA.
  • Druker BJ; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.
  • Traer E; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA.
Am J Hematol ; 96(7): E226-E229, 2021 07 01.
Article em En | MEDLINE | ID: mdl-33780043
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazinas / Leucemia Mieloide Aguda / Resistencia a Medicamentos Antineoplásicos / Inibidores de Proteínas Quinases / Tirosina Quinase 3 Semelhante a fms / Compostos de Anilina Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazinas / Leucemia Mieloide Aguda / Resistencia a Medicamentos Antineoplásicos / Inibidores de Proteínas Quinases / Tirosina Quinase 3 Semelhante a fms / Compostos de Anilina Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article