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Early prevention of cognitive impairment in the community population: The Beijing Aging Brain Rejuvenation Initiative.
Yang, Caishui; Li, Xin; Zhang, Junying; Chen, Yaojing; Li, He; Wei, Dongfeng; Lu, Peng; Liang, Ying; Liu, Zhen; Shu, Ni; Wang, Fang; Guan, Qing; Tao, Wuhai; Wang, Qingshan; Jia, Jianjun; Ai, Lin; Cui, Ruixue; Wang, Yanping; Peng, Dantao; Zhang, Wei; Chen, Kewei; Wang, Xiaomin; Zhao, Jizong; Wang, Yongyan; Dong, Qi; Wang, Jun; Zhang, Zhanjun.
Afiliação
  • Yang C; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
  • Li X; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
  • Zhang J; Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, China.
  • Chen Y; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
  • Li H; Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, China.
  • Wei D; Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, China.
  • Lu P; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
  • Liang Y; School of Biomedical Engineering, Capital Medical University, Beijing, China.
  • Liu Z; National Institute on Drug Dependence, Peking University, Beijing, China.
  • Shu N; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
  • Wang F; Dongcheng District Community Health Service Centre, Beijing, China.
  • Guan Q; School of Psychology and Society, Shenzhen University, Shenzhen, China.
  • Tao W; School of Psychology and Society, Shenzhen University, Shenzhen, China.
  • Wang Q; Beijing Northern Hospital, China North Industries Group, Beijing, China.
  • Jia J; Department of Geriatric Neurology, Chinese PLA General Hospital, Beijing, China.
  • Ai L; Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
  • Cui R; Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • Wang Y; Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, China.
  • Peng D; Department of Neurology, China-Japan Friendship Hospital, Beijing, China.
  • Zhang W; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
  • Chen K; Banner Alzheimer's Institute, Phoenix, Arizona, USA.
  • Wang X; School of Basic Medicine, Capital Medical University, Beijing, China.
  • Zhao J; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
  • Wang Y; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
  • Dong Q; Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, China.
  • Wang J; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
  • Zhang Z; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Alzheimers Dement ; 17(10): 1610-1618, 2021 10.
Article em En | MEDLINE | ID: mdl-33792187
ABSTRACT
Facing considerable challenges associated with aging and dementia, China urgently needs an evidence-based health-care system for prevention and management of dementia. The Beijing Aging Brain Rejuvenation Initiative (BABRI) is a community-based cohort study initiated in 2008 that focuses on asymptomatic stages of dementia, aims to develop community-based prevention strategies for cognitive impairment, and provides a platform for scientific research and clinical trials. Thus far, BABRI has recruited 10,255 participants (aged 50 and over, 60.3% female), 2021 of whom have been followed up at least once at a 2- or 3-year interval. This article presents aims and study design of BABRI; summarizes preliminary behavioral and neuroimaging findings on mild cognitive impairment (MCI) and results of clinical trials on MCI; and discusses issues concerning early prevention in community, MCI diagnosis methods, and applications of database of aging and dementia. BABRI is proposed to build a systematic framework on brain health in old age.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Envelhecimento / Progressão da Doença / Doença de Alzheimer / Disfunção Cognitiva Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País como assunto: Asia Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Envelhecimento / Progressão da Doença / Doença de Alzheimer / Disfunção Cognitiva Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País como assunto: Asia Idioma: En Ano de publicação: 2021 Tipo de documento: Article