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Design, synthesis, and biological activity evaluation of a series of novel sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia.
Feng, Ziying; Chen, Aiping; Shi, Jing; Zhou, Daoguang; Shi, Wei; Qiu, Qianqian; Liu, Xinhong; Huang, Wenlong; Li, Jieming; Qian, Hai; Zhang, Wenjie.
Afiliação
  • Feng Z; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China.
  • Chen A; College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing 210023, PR China; Center for Drug Evaluation, NMPA, 128 Jianguo Road, Beijing 100022, PR China.
  • Shi J; Center for Drug Evaluation, NMPA, 128 Jianguo Road, Beijing 100022, PR China.
  • Zhou D; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China.
  • Shi W; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China.
  • Qiu Q; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China.
  • Liu X; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China.
  • Huang W; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China.
  • Li J; Henan University of Traditional Chinese Medicine, Zhengzhou, 450046, Henan, PR China. Electronic address: jiemingli@hactcm.edu.cn.
  • Qian H; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China; Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China. Electronic addr
  • Zhang W; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China; Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China. Electronic addr
Bioorg Chem ; 111: 104849, 2021 06.
Article em En | MEDLINE | ID: mdl-33798846
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonamidas / Fatores de Transcrição / Desenho de Fármacos / Leucemia Mieloide Aguda / Proteínas de Ciclo Celular / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonamidas / Fatores de Transcrição / Desenho de Fármacos / Leucemia Mieloide Aguda / Proteínas de Ciclo Celular / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article