Shikonin Derivatives from <i>Onsoma visianii</i> Decrease Expression of Phosphorylated STAT3 in Leukemia Cells and Exert Antitumor Activity.

Todorovic, Zeljko; Milovanovic, Jelena; Arsenijevic, Dragana; Vukovic, Nenad; Vukic, Milena; Arsenijevic, Aleksandar; Djurdjevic, Predrag; Milovanovic, Marija; Arsenijevic, Nebojsa

Shikonin Derivatives from Onsoma visianii Decrease Expression of Phosphorylated STAT3 in Leukemia Cells and Exert Antitumor Activity.

Todorovic, Zeljko; Milovanovic, Jelena; Arsenijevic, Dragana; Vukovic, Nenad; Vukic, Milena; Arsenijevic, Aleksandar; Djurdjevic, Predrag; Milovanovic, Marija; Arsenijevic, Nebojsa.

Afiliação

Todorovic Z; Department of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Milovanovic J; Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Arsenijevic D; Department of Histology and Embriology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Vukovic N; Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Vukic M; Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Arsenijevic A; Department of Chemistry, Faculty of Science, University of Kragujevac, 34000 Kragujevac, Serbia.
Djurdjevic P; Department of Chemistry, Faculty of Science, University of Kragujevac, 34000 Kragujevac, Serbia.
Milovanovic M; Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Arsenijevic N; Department of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.

Nutrients ; 13(4)2021 Mar 31.

Article em En | MEDLINE | ID: mdl-33807148

Assuntos

Boraginaceae/química; Leucemia/metabolismo; Naftoquinonas/química; Fator de Transcrição STAT3/metabolismo; Animais; Antineoplásicos Fitogênicos/química; Antineoplásicos Fitogênicos/farmacologia; Apoptose; Linhagem Celular; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Concentração Inibidora 50; Masculino; Proteínas de Membrana; Camundongos; Camundongos Endogâmicos BALB C; Fosfoproteínas; Fator de Transcrição STAT3/genética

Palavras-chave

BCL1; JVM-13; Onosma visianii; STAT3; isobutyrylshikonin; α-methylbutyrylshikonin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia / Naftoquinonas / Boraginaceae / Fator de Transcrição STAT3 Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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