Nourin-Associated miRNAs: Novel Inflammatory Monitoring Markers for Cyclocreatine Phosphate Therapy in Heart Failure.

Elgebaly, Salwa A; Todd, Robert; Kreutzer, Donald L; Christenson, Robert; El-Khazragy, Nashwa; Arafa, Reem K; Rabie, Mostafa A; Mohamed, Ahmed F; Ahmed, Lamiaa A; El Sayed, Nesrine S

Elgebaly, Salwa A; Todd, Robert; Kreutzer, Donald L; Christenson, Robert; El-Khazragy, Nashwa; Arafa, Reem K; Rabie, Mostafa A; Mohamed, Ahmed F; Ahmed, Lamiaa A; El Sayed, Nesrine S.

Afiliação

Elgebaly SA; Research & Development, Nour Heart, Inc., Vienna, VA 22180, USA.
Todd R; Department of Surgery, School of Medicine, UConn Health, Farmington, CT 06032, USA.
Kreutzer DL; Chemistry Department, ProChem Intl, LLC, Sheboygan, WI 53085, USA.
Christenson R; Department of Surgery, School of Medicine, and Cell & Molecular Tissue Engineering, UConn Health, LLC, Farmington, CT 06032, USA.
El-Khazragy N; Department of Pathology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
Arafa RK; Department of Clinical Pathology-Hematology, Ain Shams Medical Research Institute (MASRI), Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.
Rabie MA; Biomedical Sciences Program & Drug Design and Discovery Lab, Zewail City of Science and Technology, Cairo 12578, Egypt.
Mohamed AF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
Ahmed LA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
El Sayed NS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.

Int J Mol Sci ; 22(7)2021 Mar 30.

Article em En | MEDLINE | ID: mdl-33808213

Assuntos

Imidazolidinas/farmacologia; MicroRNAs/genética; Fosfocreatina/análogos & derivados; Angina Instável/genética; Animais; Biomarcadores Farmacológicos; Insuficiência Cardíaca/tratamento farmacológico; Insuficiência Cardíaca/genética; Humanos; Imidazolidinas/metabolismo; Isoproterenol/uso terapêutico; Masculino; MicroRNAs/metabolismo; Infarto do Miocárdio/genética; Miocárdio/metabolismo; Miócitos Cardíacos/metabolismo; Fosfocreatina/genética; Fosfocreatina/metabolismo; Fosfocreatina/farmacologia; RNA Mensageiro/metabolismo; Ratos; Ratos Wistar

Palavras-chave

Nourin; cardioprotection; cyclocreatine phosphate; drug therapy response; heart failure; inflammatory mediators; miR-137 and miR-106b-5p; monitoring biomarker; myocardial ischemia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfocreatina / MicroRNAs / Imidazolidinas Tipo de estudo: Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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