The Oral Administration of Sanguisorba officinalis Extract Improves Physical Performance through LDHA Modulation.
Molecules
; 26(6)2021 Mar 12.
Article
em En
| MEDLINE
| ID: mdl-33809377
ABSTRACT
Muscle fatigue is induced by an acute or chronic physical performance inability after excessive physical activity often associated with lactate accumulation, the end-product of glycolysis. In this study, the water-extracted roots of Sanguisorba officinalis L., a herbal medicine traditionally used for inflammation and diarrhea, reduced the activities of lactate dehydrogenase A (LDHA) in in vitro enzyme assay myoblast C2C12 cells and murine muscle tissue. Physical performance measured by a treadmill test was improved in the S. officinalis-administrated group. The analysis of mouse serum and tissues showed significant changes in lactate levels. Among the proteins related to energy metabolism-related physical performance, phosphorylated-AMP-activated protein kinase alpha (AMPKα) and peroxisome proliferator-activated receptor-coactivator-1 alpha (PGC-1α) levels were enhanced, whereas the amount of LDHA was suppressed. Therefore, S. officinalis might be a candidate for improving physical performance via inhibiting LDHA and glycolysis.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
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Extratos Vegetais
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Sanguisorba
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Desempenho Físico Funcional
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Lactato Desidrogenase 5
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article