Genetically increasing flux through ß-oxidation in skeletal muscle increases mitochondrial reductive stress and glucose intolerance.

Smith, Cody D; Lin, Chien-Te; McMillin, Shawna L; Weyrauch, Luke A; Schmidt, Cameron A; Smith, Cheryl A; Kurland, Irwin J; Witczak, Carol A; Neufer, P Darrell

Smith, Cody D; Lin, Chien-Te; McMillin, Shawna L; Weyrauch, Luke A; Schmidt, Cameron A; Smith, Cheryl A; Kurland, Irwin J; Witczak, Carol A; Neufer, P Darrell.

Afiliação

Smith CD; East Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, Greenville, North Carolina.
Lin CT; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, North Carolina.
McMillin SL; East Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, Greenville, North Carolina.
Weyrauch LA; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, North Carolina.
Schmidt CA; East Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, Greenville, North Carolina.
Smith CA; Department of Biochemistry & Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, North Carolina.
Kurland IJ; East Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, Greenville, North Carolina.
Witczak CA; Department of Biochemistry & Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, North Carolina.
Neufer PD; East Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, Greenville, North Carolina.

Am J Physiol Endocrinol Metab ; 320(5): E938-E950, 2021 05 01.

Article em En | MEDLINE | ID: mdl-33813880

Assuntos

Catalase/genética; Intolerância à Glucose/genética; Mitocôndrias Musculares/metabolismo; Músculo Esquelético/metabolismo; PPAR alfa/genética; Animais; Catalase/metabolismo; Metabolismo Energético/genética; Intolerância à Glucose/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Mitocôndrias Musculares/genética; Especificidade de Órgãos/genética; Oxirredução; Estresse Oxidativo/genética; PPAR alfa/metabolismo

Palavras-chave

fat oxidation; glucose tolerance; insulin resistance; mitochondria; skeletal muscle

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Catalase / Intolerância à Glucose / Músculo Esquelético / PPAR alfa / Mitocôndrias Musculares Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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