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Reckless Generosity, Parkinson's Disease and Dopamine: A Case Series and Literature Review.
Amstutz, Deborah; Michelis, Joan Philipp; Debove, Ines; Maradan-Gachet, Marie Elise; Lachenmayer, Martin Lenard; Muellner, Julia; Schwegler, Kyrill; Krack, Paul.
Afiliação
  • Amstutz D; Department of Neurology University Hospital Bern, University of Bern Freiburgstrasse 18 3010 Bern Switzerland.
  • Michelis JP; Graduate School for Health Sciences University of Bern Mittelstrasse 43 3012 Bern Switzerland.
  • Debove I; Department of Neurology University Hospital Bern, University of Bern Freiburgstrasse 18 3010 Bern Switzerland.
  • Maradan-Gachet ME; Department of Neurology University Hospital Bern, University of Bern Freiburgstrasse 18 3010 Bern Switzerland.
  • Lachenmayer ML; Department of Neurology University Hospital Bern, University of Bern Freiburgstrasse 18 3010 Bern Switzerland.
  • Muellner J; Graduate School for Health Sciences University of Bern Mittelstrasse 43 3012 Bern Switzerland.
  • Schwegler K; Department of Neurology University Hospital Bern, University of Bern Freiburgstrasse 18 3010 Bern Switzerland.
  • Krack P; Department of Neurology University Hospital Bern, University of Bern Freiburgstrasse 18 3010 Bern Switzerland.
Mov Disord Clin Pract ; 8(3): 469-473, 2021 Apr.
Article em En | MEDLINE | ID: mdl-33816681
BACKGROUND: Impulse control disorders (ICDs) are a frequent side effect of dopamine replacement therapy (DRT) in Parkinson's disease (PD). Reckless generosity might expand the spectrum of known ICDs. CASES: Over 18 months, we encountered three PD patients exhibiting reckless generosity under DRT, leading to disastrous financial and social consequences. LITERATURE REVIEW: Except for another case series describing reckless generosity in three PD patients, only one study has examined generosity in PD patients; with findings suggesting that PD patients with ICDs are less sensitive to the aversive aspects of the lack of reciprocation in social settings. Studies with healthy individuals suggest that increased availability of dopamine might reduce social discounting and promote egalitarian behavior, and thereby increase generous behavior towards strangers. Genetic studies show that polymorphisms in dopamine D4 receptors influence generous behavior. CONCLUSIONS: Reckless generosity in PD patients with DRT might be underreported and should therefore be carefully be screened for by clinicians. A potential mechanism underlying this ICD-related behavior might be a sensitization of the mesolimbic and mesocortical dopaminergic system, leading to reduced social discounting and maladaptive reward-learning. Further research is needed to investigate the prevalence and underlying mechanisms of reckless generosity in PD patients.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article