Direct Synthesis of 3-Coumaranones with Calcium Carbide as an Acetylene Source.
Org Lett
; 23(8): 3141-3145, 2021 Apr 16.
Article
em En
| MEDLINE
| ID: mdl-33819044
ABSTRACT
A novel synthesis method for the construction of 3-coumaranones from the reaction of two molecules, calcium carbide and salicylaldehyde, was reported. Various 2-methyl-2-vinylbenzofuran-3(2H)-ones could be obtained in moderate yields in the absence of a metal catalyst. The salient features of this protocol involve widely available starting materials, an inexpensive and easy-to-handle alkyne source, and a cost-efficient route. The reaction mechanism was verified by density functional theory calculations of possible intermediates and corresponding transition states.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article