Enhanced cytarabine-induced killing in OGG1-deficient acute myeloid leukemia cells.

Owen, Nichole; Minko, Irina G; Moellmer, Samantha A; Cammann, Sydney K; Lloyd, R Stephen; McCullough, Amanda K

Owen, Nichole; Minko, Irina G; Moellmer, Samantha A; Cammann, Sydney K; Lloyd, R Stephen; McCullough, Amanda K.

Afiliação

Owen N; Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239.
Minko IG; Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239.
Moellmer SA; Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239.
Cammann SK; Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239.
Lloyd RS; Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239.
McCullough AK; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239.

Proc Natl Acad Sci U S A ; 118(11)2021 03 16.

Article em En | MEDLINE | ID: mdl-33836581

Assuntos

Antimetabólitos Antineoplásicos/farmacologia; Citarabina/farmacologia; DNA Glicosilases/genética; Leucemia Mieloide Aguda/patologia; 8-Hidroxi-2'-Desoxiguanosina/genética; Linhagem Celular Tumoral; Subunidade alfa 2 de Fator de Ligação ao Core/genética; Reparo do DNA; Humanos; Leucemia Mieloide Aguda/enzimologia; RNA Mensageiro/genética

Palavras-chave

AML therapy; DNA polymerase delta; DNA repair; DNA replication; fragile site

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Citarabina / DNA Glicosilases / Antimetabólitos Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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