Reactivation of SARS-CoV-2 infection following recovery from COVID-19.
J Infect Public Health
; 14(5): 620-627, 2021 May.
Article
em En
| MEDLINE
| ID: mdl-33848891
ABSTRACT
INTRODUCTION:
Many individuals test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA after recovering from the coronavirus disease (COVID-19), but the incidence of reactivation is unknown. We, therefore, estimated the incidence of reactivation among individuals who had recovered from COVID-19 and determined its predictors.METHODS:
In this retrospective cohort study, patients with COVID-19 were followed up for at least 14 days after two consecutive negative SARS-CoV-2 polymerase chain reaction test results obtained ≥24â¯h apart, and the frequency of SARS-CoV-2 reactivation was assessed.RESULTS:
Of the 109 patients, 29 (27%) experienced reactivation, and seven (24%) of these were symptomatic. The mean period for the real-time PCR tests for SARS-CoV-2 from negative to positive results was 17 days. Compared with patients without reactivation, those with reactivation were significantly younger and more likely to have a lymphocyte count of <1500/µL (odds ratio [OR] 0.34, 95% confidence interval [CI] 0.12-0.94) and two or fewer symptoms (OR 0.20, 95% CI 0.07-0.55) during the initial episode.CONCLUSION:
Risk-stratified surveillance should be conducted among patients who have recovered from COVID-19.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
SARS-CoV-2
/
COVID-19
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article