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Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells.
Wing, Peter A C; Keeley, Thomas P; Zhuang, Xiaodong; Lee, Jeffrey Y; Prange-Barczynska, Maria; Tsukuda, Senko; Morgan, Sophie B; Harding, Adam C; Argles, Isobel L A; Kurlekar, Samvid; Noerenberg, Marko; Thompson, Craig P; Huang, Kuan-Ying A; Balfe, Peter; Watashi, Koichi; Castello, Alfredo; Hinks, Timothy S C; James, William; Ratcliffe, Peter J; Davis, Ilan; Hodson, Emma J; Bishop, Tammie; McKeating, Jane A.
Afiliação
  • Wing PAC; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Chinese Academy of Medical Sciences (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.
  • Keeley TP; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK.
  • Zhuang X; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Lee JY; Department of Biochemistry, University of Oxford, Oxford, UK.
  • Prange-Barczynska M; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK.
  • Tsukuda S; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Morgan SB; Respiratory Medicine Unit and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Nuffield Department of Medicine, Experimental Medicine, University of Oxford, Oxford, UK.
  • Harding AC; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
  • Argles ILA; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Kurlekar S; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Noerenberg M; Department of Biochemistry, University of Oxford, Oxford, UK; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
  • Thompson CP; Peter Medawar Building for Pathogen Research, Department of Zoology, University of Oxford, Oxford, UK.
  • Huang KA; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
  • Balfe P; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Watashi K; Department of Virology II, National Institute of Infectious Diseases, Tokyo 162-8640, Japan; Department of Applied Biological Science, Tokyo University of Science, Noda 278-8510, Japan.
  • Castello A; Department of Biochemistry, University of Oxford, Oxford, UK; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
  • Hinks TSC; Respiratory Medicine Unit and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Nuffield Department of Medicine, Experimental Medicine, University of Oxford, Oxford, UK.
  • James W; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
  • Ratcliffe PJ; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK; Francis Crick Institute, London, UK.
  • Davis I; Department of Biochemistry, University of Oxford, Oxford, UK.
  • Hodson EJ; Francis Crick Institute, London, UK; Department of Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK.
  • Bishop T; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK.
  • McKeating JA; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Chinese Academy of Medical Sciences (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK. Electronic address: jane.mckeating@ndm.ox.ac.uk.
Cell Rep ; 35(3): 109020, 2021 04 20.
Article em En | MEDLINE | ID: mdl-33852916
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Replicação Viral / Células Epiteliais / Subunidade alfa do Fator 1 Induzível por Hipóxia / Internalização do Vírus / SARS-CoV-2 / COVID-19 / Glicina / Isoquinolinas / Pulmão Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Replicação Viral / Células Epiteliais / Subunidade alfa do Fator 1 Induzível por Hipóxia / Internalização do Vírus / SARS-CoV-2 / COVID-19 / Glicina / Isoquinolinas / Pulmão Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article