Single-Cell Transcriptomics and <i>In Situ</i> Morphological Analyses Reveal Microglia Heterogeneity Across the Nigrostriatal Pathway.

Uriarte Huarte, Oihane; Kyriakis, Dimitrios; Heurtaux, Tony; Pires-Afonso, Yolanda; Grzyb, Kamil; Halder, Rashi; Buttini, Manuel; Skupin, Alexander; Mittelbronn, Michel; Michelucci, Alessandro

Single-Cell Transcriptomics and In Situ Morphological Analyses Reveal Microglia Heterogeneity Across the Nigrostriatal Pathway.

Uriarte Huarte, Oihane; Kyriakis, Dimitrios; Heurtaux, Tony; Pires-Afonso, Yolanda; Grzyb, Kamil; Halder, Rashi; Buttini, Manuel; Skupin, Alexander; Mittelbronn, Michel; Michelucci, Alessandro.

Afiliação

Uriarte Huarte O; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg.
Kyriakis D; Luxembourg Center of Neuropathology (LCNP), Luxembourg, Luxembourg.
Heurtaux T; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg.
Pires-Afonso Y; Luxembourg Center of Neuropathology (LCNP), Luxembourg, Luxembourg.
Grzyb K; Department of Life Sciences and Medicine (DLSM), University of Luxembourg, Esch-sur-Alzette, Luxembourg.
Halder R; Neuro-Immunology Group, Department of Oncology (DONC), Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg.
Buttini M; Faculty of Science, Technology and Medicine, University of Luxembourg, Belvaux, Luxembourg.
Skupin A; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg.
Mittelbronn M; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg.
Michelucci A; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg.

Front Immunol ; 12: 639613, 2021.

Article em En | MEDLINE | ID: mdl-33854507

Assuntos

Microglia/patologia; Transcriptoma/genética; Animais; Corpo Estriado/patologia; Feminino; Inflamação/genética; Inflamação/patologia; Mesencéfalo/patologia; Camundongos; Neurônios/patologia; Doença de Parkinson/genética; Doença de Parkinson/patologia; Fenótipo; Análise de Sequência de RNA/métodos; Análise de Célula Única/métodos; Transcrição Gênica/genética

Palavras-chave

Parkinson's disease; cell morphology; cellular heterogeneity; immune alerted; microglia; nigrostriatal pathway; single-cell transcriptomics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microglia / Transcriptoma Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microglia / Transcriptoma Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article