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Horienoids A and B, Two Heterocoupled Sesquiterpenoid Dimers from Hedyosmum orientale.
Fan, Yao-Yue; Gan, Li-She; Chen, Shi-Xin; Gong, Qi; Zhang, Hai-Yan; Yue, Jian-Min.
Afiliação
  • Fan YY; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Gan LS; Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
  • Chen SX; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China.
  • Gong Q; Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
  • Zhang HY; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Yue JM; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
J Org Chem ; 86(16): 11277-11283, 2021 08 20.
Article em En | MEDLINE | ID: mdl-33855855
ABSTRACT
Two eudesmane-guaiane/lindenane heterocoupled sesquiterpenoid dimers, horienoids A (1) and B (2) with new carbon skeletons, from Hedyosmum orientale were characterized by a combined method. Compound 1 featured a unique 2,10-dioxabicyclo[6.2.1]undecane core moiety with an anti-Bredt bridgehead double bond. Their biogenetic pathways were proposed to involve Diels-Alder and cascade rearrangement reactions as the key steps. Compound 2 exhibited a potent anti-inflammatory effect on LPS-induced BV-2 microglial cells.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sesquiterpenos Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sesquiterpenos Idioma: En Ano de publicação: 2021 Tipo de documento: Article