Dual cure (thermal/photo) composite hydrogel derived from chitosan/collagen for in situ 3D bioprinting.
Int J Biol Macromol
; 182: 689-700, 2021 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-33857517
ABSTRACT
In situ 3D printing technologies is a new frontier for highly personalized medicine, which requires suitable bioink with rheology, biocompatibility, and gelation kinetics to support the right shape and mechanical properties of the printed construct. To this end, a facile design of thermo/photo dual cure composite hydrogel was proposed using MHBC and soluble collagen in this study. M/C composite hydrogel exhibited rapid thermo-induced sol-gel transition and contraction, tunable mechanical properties, proper microstructure and biodegradability for 3D cell culture, as well as improve cyto-compatibility, all of which were dependent upon the methacrylation degree of MHBC and M/C ratios. The printability of the optimal formulation (3% MHBC/1% collagen) was validated by its mild printing condition, rapid gelation of bioink at 37 °C and simple postprocessing manipulation. Both desirable printability and cyto-compatibility enable M/C composite hydrogel a potential candidate as bioink to be applied for in situ 3D bioprinting.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Colágeno
/
Hidrogéis
/
Quitosana
/
Impressão Tridimensional
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article