Discovery of a Highly Selective and Potent TRPC3 Inhibitor with High Metabolic Stability and Low Toxicity.

Zhang, Sicheng; Romero, Luis O; Deng, Shanshan; Wang, Jiaxing; Li, Yong; Yang, Lei; Hamilton, David J; Miller, Duane D; Liao, Francesca-Fang; Cordero-Morales, Julio F; Wu, Zhongzhi; Li, Wei

Zhang, Sicheng; Romero, Luis O; Deng, Shanshan; Wang, Jiaxing; Li, Yong; Yang, Lei; Hamilton, David J; Miller, Duane D; Liao, Francesca-Fang; Cordero-Morales, Julio F; Wu, Zhongzhi; Li, Wei.

Afiliação

Zhang S; Department of Pharmaceutical Sciences, College of Pharmacy, the University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Romero LO; Department of Physiology, the University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Deng S; Integrated Biomedical Sciences Graduate Program, College of Graduate Health Sciences, Memphis, Tennessee 38163, United States.
Wang J; Department of Pharmaceutical Sciences, College of Pharmacy, the University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Li Y; Department of Pharmaceutical Sciences, College of Pharmacy, the University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Yang L; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States.
Hamilton DJ; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States.
Miller DD; Department of Comparative Medicine, College of Graduate Health Sciences, the University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Liao FF; Department of Pharmaceutical Sciences, College of Pharmacy, the University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Cordero-Morales JF; Department of Pharmacology, Addiction Science, and Toxicology, the University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Wu Z; Department of Physiology, the University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Li W; Department of Pharmaceutical Sciences, College of Pharmacy, the University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.

ACS Med Chem Lett ; 12(4): 572-578, 2021 Apr 08.

Article em En | MEDLINE | ID: mdl-33859797

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article