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Analysis of single nucleotide polymorphisms in chronic beryllium disease.
Frye, Björn C; Gaede, Karoline I; Saltini, Cesare; Rossman, Milton D; Monos, Dimitri S; Rosenman, Ken D; Schuler, Christine R; Weston, Ainsley; Wegner, Ralf; Noth, Rainer; Zissel, Gernot; Schreiber, Stefan; Nothnagel, Michael; Müller-Quernheim, Joachim.
Afiliação
  • Frye BC; Department of Pneumology, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Killianstrasse 5, 79106, Freiburg, Germany.
  • Gaede KI; BioMaterial Bank Nord, Research Center Borstel, Leibniz Lung Center, 23845 Borstel, Parkallee 35, Germany.
  • Saltini C; Airway Research Center North, German Center for Lung Research (DZL), Wöhrendamm 80, 22927, Großhansdorf, Germany.
  • Rossman MD; Department of Medicine, University of Florida, 1600 Archer Rd, Gainesville, 32610, FL, USA.
  • Monos DS; Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, USA.
  • Rosenman KD; Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, USA.
  • Schuler CR; Division of Occupational and Environmental Medicine, Department of Medicine, Michigan State University, East Lansing, MI, USA.
  • Weston A; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA.
  • Wegner R; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA.
  • Noth R; Institute for Occupational and Maritime Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Zissel G; Institute for Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany.
  • Schreiber S; Department of Pneumology, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Killianstrasse 5, 79106, Freiburg, Germany.
  • Nothnagel M; Institute for Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany.
  • Müller-Quernheim J; Department of Statistical Genetics and Bioinformatics, Cologne Center for Genomics (CCG), University of Cologne, Cologne, Germany.
Respir Res ; 22(1): 107, 2021 Apr 16.
Article em En | MEDLINE | ID: mdl-33863318
ABSTRACT
Sarcoidosis and chronic beryllium disease (CBD) are phenocopies, however the latter one has a clear trigger factor that is beryllium exposure. This study analyses single nucleotide polymorphisms (SNPs) in a large cohort for beryllium-exposed persons. SNPs were chosen for their relevance in sarcoidosis. Even though one of largest cohorts of beryllium-exposed persons was analysed, no statistically relevant association between any SNP and CBD could be verified. Notably, some SNPs exhibit inverse OR for beryllium sensitization and CBD with nominally statistical significance, which allows hypothesizing about pathophysiological role of genes for the disease triggering and development.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Beriliose / Berílio / DNA / Exposição Ocupacional / Polimorfismo de Nucleotídeo Único / Butirofilinas Limite: Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Beriliose / Berílio / DNA / Exposição Ocupacional / Polimorfismo de Nucleotídeo Único / Butirofilinas Limite: Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article