Gefitinib Results in Robust Host-Directed Immunity Against <i>Salmonella</i> Infection Through Proteo-Metabolomic Reprogramming.

Sadhu, Srikanth; Rizvi, Zaigham Abbas; Pandey, Ramendra Pati; Dalal, Rajdeep; Rathore, Deepak Kumar; Kumar, Bhoj; Pandey, Manitosh; Kumar, Yashwant; Goel, Renu; Maiti, Tushar K; Johri, Atul Kumar; Tiwari, Ashutosh; Pandey, Amit Kumar; Awasthi, Amit

Gefitinib Results in Robust Host-Directed Immunity Against Salmonella Infection Through Proteo-Metabolomic Reprogramming.

Sadhu, Srikanth; Rizvi, Zaigham Abbas; Pandey, Ramendra Pati; Dalal, Rajdeep; Rathore, Deepak Kumar; Kumar, Bhoj; Pandey, Manitosh; Kumar, Yashwant; Goel, Renu; Maiti, Tushar K; Johri, Atul Kumar; Tiwari, Ashutosh; Pandey, Amit Kumar; Awasthi, Amit.

Afiliação

Sadhu S; Infection and Immunobiology, Translational Health Science and Technology Institute, Faridabad, India.
Rizvi ZA; Infection and Immunobiology, Translational Health Science and Technology Institute, Faridabad, India.
Pandey RP; Department of Biotechnology and Biochemistry, SRM University, Sonepat, India.
Dalal R; Infection and Immunobiology, Translational Health Science and Technology Institute, Faridabad, India.
Rathore DK; Infection and Immunity, Translational Health Science and Technology Institute, Faridabad, India.
Kumar B; Functional Proteomics Laboratory, Regional Centre for Biotechnology, Faridabad, India.
Pandey M; Infection and Immunity, Translational Health Science and Technology Institute, Faridabad, India.
Kumar Y; Non Communicable Diseases, Translational Health Science and Technology Institute, Faridabad, India.
Goel R; Non Communicable Diseases, Translational Health Science and Technology Institute, Faridabad, India.
Maiti TK; Functional Proteomics Laboratory, Regional Centre for Biotechnology, Faridabad, India.
Johri AK; Infection and Immunity, Jawaharlal Nehru University, New Delhi, India.
Tiwari A; Infection and Immunobiology, Translational Health Science and Technology Institute, Faridabad, India.
Pandey AK; Infection and Immunity, Translational Health Science and Technology Institute, Faridabad, India.
Awasthi A; Infection and Immunobiology, Translational Health Science and Technology Institute, Faridabad, India.

Front Immunol ; 12: 648710, 2021.

Article em En | MEDLINE | ID: mdl-33868285

Assuntos

Gefitinibe/farmacologia; Metabolômica/métodos; Proteômica/métodos; Infecções por Salmonella/prevenção & controle; Salmonella/efeitos dos fármacos; Animais; Células Cultivadas; Receptores ErbB/imunologia; Receptores ErbB/metabolismo; Interações Hospedeiro-Patógeno/efeitos dos fármacos; Interações Hospedeiro-Patógeno/imunologia; Humanos; Macrófagos/efeitos dos fármacos; Macrófagos/metabolismo; Macrófagos/microbiologia; Camundongos Endogâmicos C57BL; Viabilidade Microbiana/efeitos dos fármacos; Viabilidade Microbiana/imunologia; Inibidores de Proteínas Quinases/farmacologia; Salmonella/imunologia; Salmonella/fisiologia; Infecções por Salmonella/imunologia; Infecções por Salmonella/microbiologia; Transdução de Sinais/efeitos dos fármacos; Transdução de Sinais/imunologia; Células THP-1

Palavras-chave

EGFR; HIF-1α; Salmonella; acriflavin; gefitinib; host directed therapeutics; mTOR; proteo-metabolomic changes

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Salmonella / Infecções por Salmonella / Proteômica / Metabolômica / Gefitinibe Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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