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The potential role of miR-124-3p in tumorigenesis and other related diseases.
Li, Qian; Liu, Shuqing; Yan, Jinsong; Sun, Ming-Zhong; Greenaway, Frederick T.
Afiliação
  • Li Q; Department of Biotechnology, College of Basic Medical Sciences, Dalian Medical University, 9 West Section, Lvshun Southern Road, Dalian, 116044, China.
  • Liu S; Department of Hematology, Dalian Key Laboratory of Hematology, Diamond Bay Institute of Hematology, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116027, China.
  • Yan J; Department of Biochemistry, College of Basic Medical Sciences, Dalian Medical University, 9 West Section, Lvshun Southern Road, Dalian, 116044, China. lsqsmz@163.com.
  • Sun MZ; Department of Hematology, Dalian Key Laboratory of Hematology, Diamond Bay Institute of Hematology, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116027, China. lsqsmz@163.com.
  • Greenaway FT; Department of Hematology, Dalian Key Laboratory of Hematology, Diamond Bay Institute of Hematology, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116027, China.
Mol Biol Rep ; 48(4): 3579-3591, 2021 Apr.
Article em En | MEDLINE | ID: mdl-33877528
MicroRNAs (miRNAs) are a class of single-stranded noncoding and endogenous RNA molecules with a length of 18-25 nucleotides. Previous work has shown that miR-124-3p leads to malignant progression of cancer including cell apoptosis, migration, invasion, drug resistance, and also recovers neural function, affects adipogenic differentiation, facilitates wound healing through control of various target genes. miR-124-3p has been mainly previously characterized as a tumor suppressor regulating tumorigenesis and progression in several cancers, such as hepatocellular carcinoma (HCC), gastric cancer (GC), bladder cancer, ovarian cancer (OC), and leukemia, as a tumor promotor in breast cancer (BC), and it has been also widely studied in a variety of neurological diseases, like Parkinson's disease (PD), dementia and Alzheimer's disease (AD), and cardiovascular diseases, ulcerative colitis (UC), acute respiratory distress syndrome (ARDS). To lay the groundwork for future therapeutic strategies, in this review we mainly focus on the most recent years of literature on the functions of miR-124-3p in related major cancers, as well as its downstream target genes. Although current work as yet provides an incomplete picture, miR-124-3p is still worthy of more attention as a practical and effective clinical biomarker.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: MicroRNAs / Carcinogênese Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: MicroRNAs / Carcinogênese Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article