Novel 1-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-indene-4-thiol derivatives as potent selective human monoamine oxidase B inhibitors: Design, SAR development, and biological evaluation.

Kong, Haiyan; Meng, Xianshe; Hou, Rui; Yang, Xiaoxiao; Han, Jihong; Xie, Zhouling; Duan, Yajun; Liao, Chenzhong

Kong, Haiyan; Meng, Xianshe; Hou, Rui; Yang, Xiaoxiao; Han, Jihong; Xie, Zhouling; Duan, Yajun; Liao, Chenzhong.

Afiliação

Kong H; Department of Pharmaceutical Sciences and Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China.
Meng X; Department of Pharmaceutical Sciences and Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China.
Hou R; Department of Pharmaceutical Sciences and Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China.
Yang X; Department of Pharmaceutical Sciences and Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China.
Han J; Department of Pharmaceutical Sciences and Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China.
Xie Z; Department of Pharmaceutical Sciences and Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China.
Duan Y; Department of Pharmaceutical Sciences and Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China. Electronic address: yduan@hfut.edu.cn.
Liao C; Department of Pharmaceutical Sciences and Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China. Electronic address: czliao@hfut.edu.cn.

Bioorg Med Chem Lett ; 43: 128051, 2021 07 01.

Article em En | MEDLINE | ID: mdl-33887441

Assuntos

Desenho de Fármacos; Indenos/farmacologia; Inibidores da Monoaminoxidase/farmacologia; Monoaminoxidase/metabolismo; Compostos de Sulfidrila/farmacologia; Relação Dose-Resposta a Droga; Humanos; Indenos/síntese química; Indenos/química; Modelos Moleculares; Estrutura Molecular; Inibidores da Monoaminoxidase/síntese química; Inibidores da Monoaminoxidase/química; Relação Estrutura-Atividade; Compostos de Sulfidrila/síntese química; Compostos de Sulfidrila/química

Palavras-chave

Fragment-based drug design; HMAO-B; Isoform selectivity; Structure activity relationship

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Sulfidrila / Desenho de Fármacos / Indenos / Monoaminoxidase / Inibidores da Monoaminoxidase Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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