Your browser doesn't support javascript.
loading
Synthesis and biological evaluation of novel benzo[a]pyridazino[3,4-c]phenazine derivatives.
Le-Nhat-Thuy, Giang; Dang Thi, Tuyet Anh; Nguyen Thi, Quynh Giang; Hoang Thi, Phuong; Nguyen, Tuan Anh; Nguyen, Ha Thanh; Nguyen Thi, Thu Ha; Nguyen, Hoang Sa; Nguyen, Tuyen Van.
Afiliação
  • Le-Nhat-Thuy G; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam; Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam. Electronic address: lenhatthuygiang@yahoo.com.
  • Dang Thi TA; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam; Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam.
  • Nguyen Thi QG; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam; Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam.
  • Hoang Thi P; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam.
  • Nguyen TA; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam.
  • Nguyen HT; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam.
  • Nguyen Thi TH; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam.
  • Nguyen HS; University of Khanh Hoa, 1 Nguyen Chanh, Nhatrang, Khanhhoa, Viet Nam.
  • Nguyen TV; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam; Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam. Electronic address: ngvtuyen@hotmail.com.
Bioorg Med Chem Lett ; 43: 128054, 2021 07 01.
Article em En | MEDLINE | ID: mdl-33895275
ABSTRACT
A convenient microwave-assisted one-pot four-component synthetic approach was developed en route to novel functionalized benzo[a]pyridazino[3,4-c]phenazine derivatives starting from 2-hydroxy-1,4-naphthoquinone, aromatic aldehydes, methyl hydrazine and o-phenylenediamine. Nine new derivatives were successfully synthesized and subsequently evaluated in terms of their biological profiles. The results revealed good cytotoxic activities of compounds 6a, 6h against KB, HepG2, Lu1 and MCF7 human cancer cell lines. Besides that, compound 6d exhibited promising antimicrobial activities toward Staphylococcuc aureus and Bacillus subtilis bacterial strains with IC50 < 6 µM.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenazinas / Piridazinas / Staphylococcus aureus / Bacillus subtilis / Antibacterianos / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenazinas / Piridazinas / Staphylococcus aureus / Bacillus subtilis / Antibacterianos / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article