Discovery of boronic acid-based potent activators of tumor pyruvate kinase M2 and development of gastroretentive nanoformulation for oral dosing.

Patle, Rajkumar; Shinde, Shital; Patel, Sagarkumar; Maheshwari, Rahul; Jariyal, Heena; Srivastava, Akshay; Chauhan, Neelam; Globisch, Christoph; Jain, Alok; Tekade, Rakesh K; Shard, Amit

Patle, Rajkumar; Shinde, Shital; Patel, Sagarkumar; Maheshwari, Rahul; Jariyal, Heena; Srivastava, Akshay; Chauhan, Neelam; Globisch, Christoph; Jain, Alok; Tekade, Rakesh K; Shard, Amit.

Afiliação

Patle R; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research-Ahmedabad, India.
Shinde S; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research-Ahmedabad, India.
Patel S; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research-Ahmedabad, India.
Maheshwari R; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research-Ahmedabad, India.
Jariyal H; Department of Biotechnology, National Institute of Pharmaceutical Education and Research-Ahmedabad, India.
Srivastava A; Department of Biotechnology, National Institute of Pharmaceutical Education and Research-Ahmedabad, India.
Chauhan N; Department of Biotechnology, National Institute of Pharmaceutical Education and Research-Ahmedabad, India.
Globisch C; Department of Chemistry, University of Konstanz, Germany.
Jain A; Department of Biotechnology, National Institute of Pharmaceutical Education and Research-Ahmedabad, India.
Tekade RK; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research-Ahmedabad, India. Electronic address: rakeshtekade@niperahm.ac.in.
Shard A; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research-Ahmedabad, India. Electronic address: amit@niperahm.ac.in.

Bioorg Med Chem Lett ; 42: 128062, 2021 06 15.

Article em En | MEDLINE | ID: mdl-33901643

Assuntos

Antineoplásicos/farmacologia; Ácidos Borônicos/farmacologia; Proteínas de Transporte/metabolismo; Quitosana/química; Descoberta de Drogas; Trato Gastrointestinal/química; Proteínas de Membrana/metabolismo; Nanopartículas/química; Hormônios Tireóideos/metabolismo; Administração Oral; Animais; Antineoplásicos/administração & dosagem; Ácidos Borônicos/administração & dosagem; Linhagem Celular; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Relação Dose-Resposta a Droga; Composição de Medicamentos; Ensaios de Seleção de Medicamentos Antitumorais; Cabras; Humanos; Modelos Moleculares; Estrutura Molecular; Relação Estrutura-Atividade; Proteínas de Ligação a Hormônio da Tireoide

Palavras-chave

Boronic acid; Cancer; MD simulations; Nanoformulation; Pyruvate kinase M2; Thiolatedchitosan-based nanoparticles (TCNPs)

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hormônios Tireóideos / Ácidos Borônicos / Proteínas de Transporte / Trato Gastrointestinal / Quitosana / Nanopartículas / Descoberta de Drogas / Proteínas de Membrana / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google