Palladium(II)-catalyzed aerobic oxidative O-H/C-H isocyanide insertion: facile access to pyrrolo[2,1-c][1,4]benzoxazine derivatives.
Org Biomol Chem
; 19(19): 4364-4368, 2021 05 19.
Article
em En
| MEDLINE
| ID: mdl-33908987
ABSTRACT
Palladium-catalyzed aerobic oxidative cyclizations of substituted 2-(1H-pyrrol-1-yl)phenols with isocyanides via an O-H/C-H insertion cascade have been developed. This strategy provides facile access to pyrrolo[2,1-c][1,4]benzoxazine derivatives in good to excellent yields under an O2 atmosphere. The notable features of this protocol include its mild reaction conditions, atom-economy, and broad functional group tolerance.
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MEDLINE
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En
Ano de publicação:
2021
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Article