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Chemical Composition, Antibacterial Screening and Cytotoxic Activity of Chiliadenus antiatlanticus (Asteraceae) Essential Oil.
El Yaagoubi, Mohamed; Ortiz, Sergio; Mechqoq, Hicham; Cavaleiro, Carlos; Lecsö-Bornet, Marylin; Rodrigues, Maria João; Custódio, Luísa; El Mousadik, Abdelhamid; Grougnet, Raphaël; El Aouad, Noureddine; Msanda, Fouad; Kritsanida, Marina.
Afiliação
  • El Yaagoubi M; Laboratory of Biotechnologies and Valorization of Natural Resources, Faculty of Sciences, University Ibn Zhor, 80060, Agadir, Morocco.
  • Ortiz S; Natural products, Analysis, Synthesis, UMR CNRS 8038 CiTCoM, Faculty of Pharmacy, University of Paris, 75006, Paris, France.
  • Mechqoq H; Laboratory of Biotechnologies and Valorization of Natural Resources, Faculty of Sciences, University Ibn Zhor, 80060, Agadir, Morocco.
  • Cavaleiro C; Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Health Sciences Campus, Azinhaga de S. Comba, 3000-548, Coimbra, Portugal.
  • Lecsö-Bornet M; Chemical Process Engineering and Forest Products Research Center, Universidade de Coimbra, Rua Sílvio Lima, Polo II, 3030-790, Coimbra, Portugal.
  • Rodrigues MJ; Natural products, Analysis, Synthesis, UMR CNRS 8038 CiTCoM, Faculty of Pharmacy, University of Paris, 75006, Paris, France.
  • Custódio L; Center of Marine Sciences, Faculty of Sciences and Technology, University of Algarve, Ed. 7, Campus of Gambelas, 8005-139, Faro, Portugal.
  • El Mousadik A; Center of Marine Sciences, Faculty of Sciences and Technology, University of Algarve, Ed. 7, Campus of Gambelas, 8005-139, Faro, Portugal.
  • Grougnet R; Laboratory of Biotechnologies and Valorization of Natural Resources, Faculty of Sciences, University Ibn Zhor, 80060, Agadir, Morocco.
  • El Aouad N; Natural products, Analysis, Synthesis, UMR CNRS 8038 CiTCoM, Faculty of Pharmacy, University of Paris, 75006, Paris, France.
  • Msanda F; Laboratory of Biotechnologies and Valorization of Natural Resources, Faculty of Sciences, University Ibn Zhor, 80060, Agadir, Morocco.
  • Kritsanida M; Research Team on Biological Engerineering, Agrifood and Aquaculture, Polydisciplinary Faculty of Larache, University Abdelmalek Essaadi, Tétouan, Route de Rabat, 92000, Larache, Morocco.
Chem Biodivers ; 18(6): e2100115, 2021 Jun.
Article em En | MEDLINE | ID: mdl-33915026
ABSTRACT
The chemical composition and in vitro antibacterial and cytotoxic activities of the essential oil (EO) of Chiliadenus antiatlanticus (Emb. & Maire) Gómiz, an asteraceous species endemic to the southwest of Morocco, were investigated. The EO yield was 1.07±0.28 %, twenty-seven metabolites were identified representing more than 96.4 % of the total composition. Camphor (35.7 %) and derivatives, borneol (4.9 %) and camphene (4.2 %) together with intermedeol (19.9 %), α-pinene (15.5 %) and (E)-pinocarveol (4.1 %) were the major constituents. An antibacterial activity was noticed against 24 strains (all Gram-positive) out of 71 at MICs values=100 µg/mL. The EO also showed significant toxicity towards liver HepG2 (55.8 % of cell viability) and melanoma B16 4A5 (41.6 % of cell viability) tumor cell lines at 100 µg/mL.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Óleos Voláteis / Asteraceae / Bactérias Gram-Positivas / Antibacterianos / Antineoplásicos Fitogênicos Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Óleos Voláteis / Asteraceae / Bactérias Gram-Positivas / Antibacterianos / Antineoplásicos Fitogênicos Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article